凋亡PCR芯片（384HT）可以用于檢測370個凋亡或細胞程序性死亡相關(guān)的關(guān)鍵基因。這款芯片涵蓋的基因包括：TNF配體及相應(yīng)受體，bcl-2蛋白家族，BIRC結(jié)構(gòu)域蛋白，CARD結(jié)構(gòu)域蛋白，死亡效應(yīng)結(jié)構(gòu)域蛋白，TRAF結(jié)構(gòu)域蛋白和半胱天冬酶。這370個基因可以按功能分類，分別在凋亡，DNA損失，氧化應(yīng)激，或胞內(nèi)和胞外信號等過程中發(fā)揮作用。通過實時定量PCR方法，研究者可以方便并且可信地對凋亡相關(guān)基因的表達進行集中分析。
Caspases & Regulators: Caspases: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CFLAR (CASPER), CRADD, CARD18, CARD17, MALT1, PYCARD, RFWD2 (COP1). Caspase Activators: AIFM3, APAF1, BAX, BBC3, BCL2L10, BCL2L13, CASP1, CASP8AP2, CASP9, COL4A3, CYCS, DIABLO (SMAC), EIF2AK3, F2, F2R, FOXL2, HIP1, HSPE1, IFNB1, IFT57, LCK, MAP3K5, MOAP1, MTCH1, MYC, NLRC4, NLRP1, NLRP12, NLRP2, NLRP3, NOD1, PMAIP1, PYCARD, STAT1, TNFRSF10A, TNFRSF10B, TNFSF15, TP53, TPD52L1, VCP. Caspase Inhibitors: BIRC5, CD27 (TNFRSF7), DHCR24, HBXIP, IFI6, SFN, TNFAIP8, TNFSF14, TRIAP1, XIAP. Anti-Apoptosis: Positive Regulation: BCL2L1 (BCL-X), BRE, CD28, ERC1, MAPK8IP2, OPA1, PRKAA1, RASA1. Negative Regulation: PIK3R2, RTN4, TNFAIP8. Other genes: AATF, AKT1, ALOX12, ANXA1, ANXA4, API5, ATF5, AVEN, AZU1, BAG1, BAG3, BAG4, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BDNF, BECN1, BFAR, BIRC2, BIRC3, XIAP, BIRC5, BIRC6, BIRC7, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CBX4, CCL2, CD27, CD40LG, CEBPB, CFDP1, CFL1, CFLAR, CRYAA, CRYAB, DAD1, DDAH2, DHCR24, EEF1A2, FAIM, FAIM2, FAS, FOXO1, GDNF, GFRAL, GLO1, GSTP1, HBXIP, HTT, HDAC1, HDAC3, HIPK3, HMGB1, HSP90B1, HSPA1B, HSPA9, HSPB1, HTATIP2, IER3, IFI6, IGF1R, IL10, IL1A, IL2, IL31RA, MALT1, MCL1, MKL1, MPO, MTL5, MYBL2, MYO18A, NAIP, NFKB1, NME5, NOL3, NOTCH2, NPM1, NRG2, NTF3, PAK7, PAX7, PEA15, PIK3CA, PIM2, POGK, POLB, PRDX2, PRKCZ, PRLR, PROK2, PSEN1, RELA, RNF7, SEMA4D, SERPINB2 (PAI-2), SERPINB9, SFRP1, SH3GLB1, SNCA, SOCS2, SOCS3, SON, SPHK1, SPP1, STAMBP, TAX1BP1, TBX3, TGFB1, TIAF1, TNF, TNFAIP3, TNFAIP8, TNFRSF10D, TNFRSF18, TNFRSF6B, TNFSF18, TPT1, TRIAP1, TSC22D3, TMX1, VEGFA, VHL, YWHAZ, ZC3HC1. Induction of Apoptosis: Death domain receptors: BID, CRADD, DAXX, DEDD2, FADD, IL18, TNF, TNFRSF10B. DNA damage: ABL1, AIFM1, BCL3, BRCA1, CHEK2 (RAD53), CIDEA, CIDEB, DYRK2, IFI16, MBD4, MSH6, PCBP4, PML, SFN, TP53, TP73. Oxidative stress: GPX1, PRODH, RNF7, TP53I3 Extracellular signals: ADORA1, BTK, CASP8AP2, CD28, CD38, CD5, CFLAR (CASPER), DAP, DAP3, DAPK1, DPF2, FASTK, MAP3K5, NDUFA13, PDCD6, PRKCA, RIPK3, SPN, TIMP3, TNFRSF25. Intracellular signals: CDKN1A, CUL1, CUL2, CUL3, CUL4A, CUL5, HIPK2, MYC, SART1. Other genes: ACVR1B, AIFM2, AIFM3, ALOX15B, APOE, BAD, BAK1, BAX, BBC3, BCL10, BCL2L11, BCL2L13, BCLAF1, BIK, BNIP1, BNIP3, BNIP3L, BOK, CASP10, CASP3, CASP4, CASP6, CD2, CD27, CD70, CEBPB, CIDEC, COL4A3, DAPK2, DAPK3, DCC, DDX20, DEDD, DIABLO (SMAC), EI24, ERCC2, ERCC3 (XPB), ERN1, ERN2, FAS, FASLG, FEM1B, FOXL2, FOXO3, HRK, HTATIP2, IFNA2, IFNB1, IFNG, IKBKG, IKBIP, IL19, INHA, INHBA, JMY, LALBA, LCK, LTA, MAL, MAP3K10, MAPK1, MX1, NDUFS3, NGFR, NLRP1, NLRP3, NME3, NOTCH2, NOX5, NUDT2, NUPR1, PDCD5, PLAGL1, PLAGL2, PLEKHF1, PLG, PMAIP1, PPP1R13B, PPP2CA, PPP2R1A, PPP2R1B, PRKCE, PRKRA, PRUNE2, PTEN, PTH, PYCARD, RPS3A, RUNX3, S100B, SAP30BP, SERINC3, SIPA1, SMNDC1, SST, SSTR3, STK17A, STK17B, TBX5, TIA1, TIAL1, TLR2, TNFRSF10A, TNFRSF19, TNFRSF9, TNFSF10, TNFSF14, TNFSF8, TP53BP2, TP63, TPD52L1, TRADD, TRAF3, TRAIP, UNC13B, UTP11L, ZNF443. TNF Domain: EDA, FASLG (TNFSF6), LTA, LTB, TNF, TNFSF10, TNFSF14, TNFSF15, TNFSF8. TNFR Domain: CD27 (TNFRSF7), CD40 (TNFRSF5), FAS (TNFRSF6), LTBR, NGFR, TNFRSF10A, TNFRSF10B, TNFRSF10D, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF6B, TNFRSF8, TNFRSF9. BCL2 and BAG Domain: BAG1, BAG3, BAG4, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L2, MCL1. BIR Domain: BIRC2 (c-IAP2), BIRC3 (c-IAP3), BIRC5, BIRC6, BIRC7, BIRC8, NAIP (BIRC1), XIAP. CARD Domain: APAF1, BCL10, BIRC2 (c-IAP2), BIRC3 (c-IAP1), CARD10, CARD11, CARD14, CARD6, CARD9, CASP1, CASP2, CASP4, CASP5, CASP9, CRADD, CARD18, CARD17, NLRP1,NOD1, NOD2, NOL3, PYCARD, RFWD2 (COP1), RIPK2. DEATH Domain: CRADD, DAPK1, EDAR, FADD, PIDD, MALT1, NFKB1, NFKB2, NGFR, RIPK1, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD. TRAF Domain: TRAF2, TRAF3, TRAF5, TRAF7. Other Regulators of Apoptosis: BCL6, CEBPG, DBP, DDIT3 (GADD153/CHOP), GRM4, LGALS1, MADD, MAPK8, NKX3-2, POU4F1, PROP1, RARG, STAT5A, STAT5B, TBK1, TDGF1, TRAF6, ZAK.

凋亡PCR芯片 384孔板Apoptosis PCR Array 384HT,凋亡PCR芯片 384孔板Apoptosis PCR Array 384HT

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