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61655-58-1 詢問

MK-212(一鹽酸鹽)(MK-212 HCl)

CAS: 61655-58-1

化學(xué)式: C8H12Cl2N4

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中文名	MK-212(一鹽酸鹽)
英文名	MK-212 HCl
別名	MK-212(一鹽酸鹽) 2-氯-6-哌嗪吡嗪鹽酸鹽 2-氯-6-(哌嗪-1-基)吡嗪鹽酸鹽
英文別名	NSC 31732 MK-212 HCl MK-212 (monohydrochloride) 2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride 2-chloro-6-(piperazin-1-yl)pyrazine hydrochloride 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride
CAS	61655-58-1
EINECS	262-883-0
化學(xué)式	C8H12Cl2N4
分子量	235.11368
溶解度	DMSO: ≥ 20 mg/mL
存儲(chǔ)條件	Inert atmosphere,2-8°C
外觀	粉末
顏色	white to off-white
產(chǎn)品用途	Description:?MK-212 is a 5HT2C-receptor agonist. A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice.
靶點(diǎn)	5-HT2C receptor agonist
危險(xiǎn)品標(biāo)志	T - 有毒物品
風(fēng)險(xiǎn)術(shù)語	25 - 吞食有毒。
安全術(shù)語	45 - 若發(fā)生事故或感不適，立即就醫(yī)(可能的話，出示其標(biāo)簽)。
危險(xiǎn)品運(yùn)輸編號(hào)	UN 2811 6.1 / PGIII
WGK Germany	3
參考資料 展開查看	1: Kozhevnikova LM, Mesitov MV, Moskovtsev AA. [Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II]. Patol Fiziol Eksp Ter. 2014 Oct-Dec;(4):17-29. Russian. PubMed PMID: 25980223. 2: Kuznetsova EG, Amstislavskaya TG, Bulygina VV, Tibeikina MA, Popova NK. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med. 2006 Nov;142(5):594-7. PubMed PMID: 17415471. 3: de Mello Cruz AP, Pinheiro G, Alves SH, Ferreira G, Mendes M, Faria L, Macedo CE, Motta V, Landeira-Fernandez J. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl). 2005 Nov;182(3):345-54. Epub 2005 Oct 19. PubMed PMID: 16133141. 4: Halford JC, Lawton CL, Blundell JE. The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence. Pharmacol Biochem Behav. 1997 Jan;56(1):41-6. PubMed PMID: 8981607.

61655-58-1 - 配置溶液濃度參考

	1mg	5mg	10mg
1 mM	4.253 ml	21.266 ml	42.533 ml
5 mM	0.851 ml	4.253 ml	8.507 ml
10 mM	0.425 ml	2.127 ml	4.253 ml
5 mM	0.085 ml	0.425 ml	0.851 ml

最后更新：2024-01-02 23:10:35