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99-24-1 詢問

沒食子酸甲酯(Methyl gallate)

CAS: 99-24-1

化學式: C8H8O5

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中文名	沒食子酸甲酯
英文名	Methyl gallate
別名	三羥基苯甲酸 沒食子酸甲酯 沒食子酸甲酯(五倍子酸甲酯 3,4,5-三羥基苯甲酸甲酯 S**3,4,5-三羥基苯甲酸甲酯
英文別名	METHYGALLATE Methyl gallate METHYLGALLATE(RG) Methyl 3,4,5-trihydroxybenzoate methyl 3,4,5-trihydroxy benzoate 3,4,5-trihydroxy-benzoic acidd methyl ester METHYL GALLATE(METHYL 3,4,5-TRIHYDROXYBENZOATE ) 2-diazo-1-naphthol-5-sulfonic acid, ester with novolac Gallic acid methyl ester, Methyl 3,4,5-trihydroxybenzoate 3,4,5-trihydroxybenzoic acid methyl ester (intermediate of bifendate)
CAS	99-24-1
EINECS	202-741-7
化學式	C8H8O5
分子量	184.15
InChI	InChI=1/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3
InChIKey	FBSFWRHWHYMIOG-UHFFFAOYSA-N
密度	1.3840 (rough estimate)
熔點	201-204°C
沸點	278.08°C (rough estimate)
閃點	190.8°C
水溶性	SOLUBLE IN HOT WATER
蒸汽壓	1.02E-08mmHg at 25°C
溶解度	乙醇: 50mg/ml，澄清
折射率	1.5690 (estimate)
酸度系數(shù)	8.04±0.23(Predicted)
存儲條件	Inert atmosphere,Room Temperature
敏感性	Easily absorbing moisture
外觀	結晶性粉末
顏色	White to slightly beige
Merck	14,4345
BRN	2113180
物化性質	單斜棱狀結晶（甲醇）。熔點為201-203℃（157℃，水合物或溶劑化的結晶）。溶于熱水、乙醇、乙醚。
MDL號	MFCD00002194
體外研究	The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H 2 O 2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H 2 O 2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
危險品標志	Xn - 有害物品 Xi - 刺激性物品
風險術語	R22 - 吞食有害。 R36/37/38 - 刺激眼睛、呼吸系統(tǒng)和皮膚。 R43 - 與皮膚接觸可能致敏。
安全術語	S26 - 不慎與眼睛接觸后，請立即用大量清水沖洗并征求醫(yī)生意見。 S36/37 - 穿戴適當?shù)姆雷o服和手套。 S24/25 - 避免與皮膚和眼睛接觸。
WGK Germany	3
RTECS	LW8000000
TSCA	Yes
海關編號	29182900
上游原料	沒食子酸
下游產(chǎn)品	沒食子酸辛酯 3,4,5-三羥甲苯
參考資料 展開查看	1. 周坤, 簡平, 梁文儀,等. 基于UPLC-Q-Exactive Orbitrap-MS分析藏藥訶子與毛訶子化學成分[J]. 質譜學報, 2020, 041(003):254-267. 2. 梁文儀, 亓旗, 梁林金,等. 基于化學計量學分析的訶子藥材高效液相色譜指紋圖譜研究[J]. 世界科學技術-中醫(yī)藥現(xiàn)代化, 2018, 20(09):167-171. 3. 梁林金, 亓旗, 葉婷,等. 基于總鞣質和7種成分同時測定的訶子藥材質量控制研究[J]. 世界科學技術:中醫(yī)藥現(xiàn)代化, 2018, 20(09):1638-1644. 4. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 5. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 6. [IF=4.952]?Ren-You Gan et al."Pigmented edible bean coats as natural sources of polyphenols with antioxidant and antibacterial effects."Lwt Food Sci Technol. 2016 Nov;73:168 7. [IF=3.935]?Li Li et al."Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC–MS and in silico docking."J Pharmaceut Biomed. 2019 Feb;164:241 8. [IF=6.312]?Yue Zhou et al."Optimization of Ultrasound-Assisted Extraction of Antioxidant Polyphenols from the Seed Coats of Red Sword Bean (Canavalia gladiate (Jacq.) DC.)."Antioxidants-Basel. 2019 Jul;8(7):200 9. [IF=5.645]?Zhang-Zhen Bai et al."Comparative investigation on metabolites and biological activities of Paeonia ostii stamens from different geographical regions of China."Ind Crop Prod. 2021 Nov;172:114038 10. [IF=4.36]?Li-Mei Feng et al."An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropathic pain by the combination of partial least-squares regression and multi-index comprehensive method."J Ethnopharmacol. 2020 Oc 11. [IF=5.246]?Wei Gu et al."Investigation of Tannins Transformation in Sanguisorbae Radix Over Carbonizing by Stir-Frying."Front Mol Biosci. 2022; 9: 762224

99-24-1 - 簡介

沒食子酸甲酯（Methyl gallate）是一種有機化合物。它是沒食子酸和甲醇反應而得到的酯類化合物。

沒食子酸甲酯的性質：
- 外觀：紅色或橙色結晶固體。
- 溶解性：易溶于乙醇、丙酮和乙醚，不溶于水。

沒食子酸甲酯的用途：

沒食子酸甲酯的制法：
沒食子酸甲酯可以通過沒食子酸和甲醇的酯化反應得到。反應條件一般是在加熱條件下，使用酸性催化劑進行。

沒食子酸甲酯的安全信息：
- 這種化合物屬于低毒化合物，但應注意避免接觸皮膚和吸入。
- 使用過程中應注意防護措施，戴手套和防護眼鏡等。
- 儲存時應避免高溫、火源和陽光直射。
在使用前請仔細閱讀相關標簽和安全說明，并嚴格按照操作規(guī)程進行。最后更新：2024-04-09 15:16:52