詳細(xì)說明
應(yīng)用； An irreversible a1B-adrenoceptor alkylating agent
CAS號碼: 70107-07-2
分子量: 408.58
分子式: C13H17Cl3N4•2HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 參考分析證明 大量特定數(shù)據(jù) (包括水 含量). Chloroethylclonidine dihydrochloride is an irreversible α1B-adrenoceptor alkylating agent.
參考文獻(xiàn)
Leclerc, G., et al., Studies on some para-substituted clonidine derivatives that exhibit an å-adrenoceptor stimulant activity. Br. J. Pharmacol. 71, 5-9, (1980) Takanashi, M, et al., Potent inhibitory action of chloroethyl-clonidine on the positive inotropic effect and phosphoinositide hydrolysis mediated via myocardial å1-adrenoceptors in the rabbit ventricular myocardium. Naunyn Schmiedebergs Arch. Pharmacol. 343, 669-673, (1991) Xiao, L., and Jeffries, W.B., Kinetics of alkylation of cloned rat å1-adrenoceptor subtypes by chloroethylclonidin. Eur. J. Pharmacol. 347, 319-327, (1998)
物理狀態(tài) :
Solid
溶解度 :
Soluble in 0.1 M NaOH: 1 mg/mL Stable for 24 hours at 4 °C.: water: 12 mg/mL Stable for 24 hours at 4 °C.: methanol: 17 mg/mL Stable for 24 hours at 4 °C.: aqueous base: unstable
僅供科研使用。不可用于診斷或治療。
運(yùn)輸 :
UN 2811, Class 6.1, Packing group II
PubChem CID :
11957477
SMILES :
CN(CCCl)CC1=CC(=C(C(=C1)Cl)NC2=NCCN2)Cl.Cl.Cl
400-6226-992