VAS2870

簡介生物活性靶點體外研究 用途與合成方法 MSDS VAS2870價格(試劑級) 上下游產(chǎn)品信息

中文名稱	VAS2870
中文同義詞	化合物VAS2870;2-((3-芐基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫代)苯并[D]惡唑;VAS 2870,NADPH氧化酶抑制劑;2-((3-芐基-3H- [1,2,3]三唑并[4,5-D]嘧啶-7-基)硫基)苯并[D]惡唑
英文名稱	1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
英文同義詞	1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide;7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine;7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine;VAS 2870;VAS2870;VAS-2870;NOX Inhibitor III, VAS2870;2-(3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ylthio)benzo[d]oxazole
CAS號	722456-31-7
分子式	C18H12N6OS
分子量	360.39
EINECS號
相關(guān)類別
Mol文件	722456-31-7.mol
結(jié)構(gòu)式

VAS2870 性質(zhì)

VAS2870 用途與合成方法

簡介

VAS-2870 (722456-31-7) 是一種 NAD(P)H 氧化酶 (Nox) 抑制劑。其可抑制 HL-60 細(xì)胞中 由PMA 誘導(dǎo)的氧化反應(yīng)(IC50=2 μM)，可 增強 TGF-β 誘導(dǎo)的肝腫瘤細(xì)胞的凋亡。

生物活性

VAS2870是一種泛NADPH oxidase(NOX)抑制劑。

靶點

體外研究

VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells.

安全信息

MSDS信息

VAS2870 價格(試劑級)

VAS2870 上下游產(chǎn)品信息