1-(2-噻唑基偶氮)-2-萘酚

生物活性靶點體外研究體內(nèi)研究 用途與合成方法 MSDS 1-(2-噻唑基偶氮)-2-萘酚價格(試劑級) 上下游產(chǎn)品信息

中文名稱	1-(2-噻唑基偶氮)-2-萘酚
中文同義詞	1-(2-噻唑基偶氮)-2-萘酚;1-(2-噻唑偶氮)-2-萘酚;1-(2'-噻唑基偶氮)-2-萘酚;2-(2-羥基-1-萘基偶氮)噻唑;1-(2-聯(lián)氮噻吩)-2-萘酚;1-(2’-噻唑偶氮)-2-萘酚;TAN[=1-(2-噻唑偶氮)-2-萘酚][過渡金屬類用分光光度試劑];TAN[=1-(2-噻唑偶氮)-2-萘酚](>99.0%(T))
英文名稱	1-(2-THIAZOLYLAZO)-2-NAPHTHOL
英文同義詞	TAN;2-(2-Hydroxy-1-naphthylazo)thiazole,  TAN;Nitrilotantalum(III);1-(Thiazole-2-ylazo)-2-naphthol;1-(Thiazole-2-ylazo)naphthalene-2-ol;1-[(Thiazole-2-yl)azo]-2-naphthol;TAN  [=1-(2-Thiazolylazo)-2-naphthol];TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals]
CAS號	1147-56-4
分子式	C13H9N3OS
分子量	255.3
EINECS號	214-555-3
相關(guān)類別	試劑和補充物;Analytical Chemistry;Azo Compounds;Chelating Reagents;Naphthylazo Compounds
Mol文件	1147-56-4.mol
結(jié)構(gòu)式

1-(2-噻唑基偶氮)-2-萘酚 性質(zhì)

1-(2-噻唑基偶氮)-2-萘酚 用途與合成方法

生物活性

NSC139021 (ERGi-USU) 是ERG陽性癌細胞生長的高度選擇性抑制劑，抑制不同細胞系的 IC50 值為 30 到400 nM。

靶點

IC50: 30 to 400 nM (ERG-positive cancer cells)

體外研究

NSC139021 selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines. The IC     ₅₀    of NSC139021 for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM. Combination of NSC139021 with enzalutamide shows additive effects in inhibiting growth of VCaP cells. A screen of kinases reveal that NSC139021 directly bound the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.

體內(nèi)研究

NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. .

安全信息

MSDS信息

1-(2-噻唑基偶氮)-2-萘酚 價格(試劑級)

1-(2-噻唑基偶氮)-2-萘酚 上下游產(chǎn)品信息