吡咯烷二硫代甲酸銨鹽

用途生物活性靶點體外研究體內研究 用途與合成方法 MSDS 吡咯烷二硫代甲酸銨鹽價格(試劑級) 上下游產品信息 專題

中文名稱	吡咯烷二硫代甲酸銨鹽
中文同義詞	吡咯烷二硫代甲酸銨;四次甲基二硫代氨基甲酸銨;四亞甲基二硫代氨基甲酸銨;1-吡咯烷硫代羧酸銨鹽/吡咯二硫代甲酸銨;1-吡咯烷羰基二硫酸銨鹽;N-吡咯烷二硫代甲酸銨;1-吡咯烷硫代羧酸銨鹽、吡咯二硫代甲酸銨、1-吡咯烷二硫代羧酸銨鹽;吡咯烷二硫代甲酸銨鹽
英文名稱	Ammonium 1-pyrrolidinedithiocarbamate
英文同義詞	1-Pyrrolidinecarbodithioic acid, ammonium salt,95%;Ammonium Pyrrolidine-N-dithiocarba;PDTC Pyrrolidinedithiocarbamate, ammonium derivative;Ammonium pyrrolidinedithiocarbamate,1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC;Ammonium pyrrolidine;1-Pyrrolidinecarbodithioic acid, aMMoniuM salt, 98% 25GR;Ammonium Pyrrolidine-N-dithiocarbamate 1-Pyrrolidinecarbodithioic Acid Ammonium Salt Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMO
CAS號	5108-96-3
分子式	C5H9NS2.H3N
分子量	164.3
EINECS號	225-834-4
相關類別	有機化工原料;生化試劑;酶抑制劑;細胞信號和神經生物學;細胞生物學試劑;化學試劑;化工原料;生化試劑-其他化學試劑;合成材料中間體-高分子材料;有機原料;醫(yī)藥中間體;細胞生物學;Nitric Oxide;標準品;格氏試劑;中藥對照品;有機化工原料;通用生化試劑-有機酸
Mol文件	5108-96-3.mol
結構式

吡咯烷二硫代甲酸銨鹽 性質

吡咯烷二硫代甲酸銨鹽 用途與合成方法

用途

吡咯烷二硫代甲酸銨鹽在包括金屬螯合作用在內的生物化學應用中很有用。它被用來防止一氧化氮合酶的誘導。抑制白血病HL-60細胞的凋亡也是非常重要的。

生物活性

Pyrrolidinedithiocarbamate ammonium  (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt)是NF-κB的有效抑制劑，抑制IκB磷酸化、阻止NF-κB易位入核并減少下游細胞因子的表達。

靶點

體外研究

Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.  
 Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.  
 Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.

體內研究

The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.

安全信息

MSDS信息

吡咯烷二硫代甲酸銨鹽 價格(試劑級)

吡咯烷二硫代甲酸銨鹽 上下游產品信息