六氫姜黃素

生物活性靶點(diǎn)體外研究體內(nèi)研究 用途與合成方法 MSDS 六氫姜黃素價格(試劑級) 上下游產(chǎn)品信息

中文名稱	六氫姜黃素
中文同義詞	六氫姜黃素;六氫姜黃素?, BR;COX-2抑制劑(HEXAHYDROCURCUMIN);六氫姜黃素 標(biāo)準(zhǔn)品;5-羥基-1,7-雙(4-羥基-3-甲氧基苯基)庚烷-3-酮
英文名稱	HEXAHYDROCURCUMIN
英文同義詞	HEXAHYDROCURCUMIN;5-Hydroxy-1-(4-hydroxy-3-Methoxycyclohexyl)-7-(4-hydroxy-3-Methoxyphenyl)heptan-3-one;(RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;1,7-Bis(3-methoxy-4-hydroxyphenyl)-5-hydroxy-3-heptanone;1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyheptan-3-one;5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;Hexahydrocurcumin, BR;3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-
CAS號	36062-05-2
分子式	C21H26O6
分子量	374.43
EINECS號
相關(guān)類別	細(xì)胞生物學(xué)試劑;對照品;中藥對照品;標(biāo)準(zhǔn)品;植物提取物;標(biāo)準(zhǔn)品 -對照藥材;其它酚類;標(biāo)準(zhǔn)品，對照品;對照品;標(biāo)準(zhǔn)品-對照品
Mol文件	36062-05-2.mol
結(jié)構(gòu)式

六氫姜黃素 性質(zhì)

六氫姜黃素 用途與合成方法

生物活性

Hexahydrocurcumin 是姜黃素的主要代謝產(chǎn)物之一，是一種選擇性的口服活性 COX-2 抑制劑，對 COX-1 無活性。Hexahydrocurcumin 具有抗氧化，抗癌和抗炎的作用。

靶點(diǎn)

體外研究

Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC     ₅₀    values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.  
 Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 μM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.  
 Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 μM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.  
 Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E     ₂    (PGE     ₂    ) in murine macrophages (RAW 264.7) in a concentration-dependent manner.

Cell Viability Assay

RT-PCR

Western Blot Analysis

體內(nèi)研究

Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats.

安全信息

MSDS信息

六氫姜黃素 價格(試劑級)

六氫姜黃素 上下游產(chǎn)品信息