蛙皮素

生物活性體外研究 用途與合成方法 MSDS 蛙皮素價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息

中文名稱	蛙皮素
中文同義詞	黃蛙素;兩棲藍(lán)素;蛙皮素,胃泌素;鈴蟾肽;蛙皮素;蛙皮素, ≥97% (HPLC);BOMBESIN ACETATE SALT HYDRATE 蛙皮素;BOMBESIN肽
英文名稱	Bombesin
英文同義詞	Bombesin  hydrate  acetate  salt;Bombesin acetate salt hydrate;2-l-glutamine-6-l-asparagine-alytesi;bombesin acetate;Bombesin, Free Base;BOMBESIN SYNTHETIC >97% STIMULATES GASTR IN RE;BOMBESIN;bombesin acetate hydrate
CAS號(hào)	31362-50-2
分子式	C71H110N24O18S
分子量	1619.85
EINECS號(hào)
相關(guān)類別	多肽類;細(xì)胞生物學(xué);蛋白質(zhì)/多肽;細(xì)胞信號(hào)和神經(jīng)生物學(xué);多肽;多肽-客戶肽;目錄肽;目錄多肽;Neuromedins and related;Peptide
Mol文件	31362-50-2.mol
結(jié)構(gòu)式

蛙皮素 性質(zhì)

蛙皮素 用途與合成方法

生物活性

Bombesin是一種最初從青蛙皮膚中分離的十四肽; 在胃泌素釋放和G蛋白受體活化中起重要作用。

體外研究

Bombesin is a tetradecapeptide with a COOH terminus ending in Gly-His-Leu-Met-NH2 and subsequently is shown to closely resemble two mammalian bombesin -related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB). Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is also found in mammalian brain, with its highest concentration in the hypothalamus. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor (IC     ₅₀    =1 nM).

多肽

蛙皮素是由14個(gè)氨基酸組成的多肽，是從鈴蟾皮膚提取的一種多肽物質(zhì)。蛙皮素的主要生理功能是通過神經(jīng)調(diào)節(jié)促進(jìn)胃竇胃泌素的釋放和胃酸分泌，促進(jìn)胰酶分泌，刺激膽囊收縮。同時(shí)彈力蛋白還能刺激胰島素、胰高血糖素和胰多肽的釋放，促進(jìn)紅細(xì)胞生成素的釋放，刺激腎素一血管緊張素系統(tǒng)，并有升高血糖、調(diào)節(jié)體溫和收縮支氣管的作用。

參考質(zhì)量標(biāo)準(zhǔn)

外觀:白色粉末
純度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
內(nèi)毒素≤50EU/mg
氨基酸組成分析≤±10%

安全信息

MSDS信息

蛙皮素 價(jià)格(試劑級(jí))

蛙皮素 上下游產(chǎn)品信息