尿酸

簡介生物活性靶點體外研究體內(nèi)研究 用途與合成方法 MSDS 尿酸價格(試劑級) 上下游產(chǎn)品信息 專題

中文名稱	尿酸
中文同義詞	尿酸;2,6,8-三羥基嘌呤;尿酸,標(biāo)準(zhǔn)液;尿酸,參比液;2,6,8,-三羥基尿雜環(huán);2,6,8,-三羥基嘌呤;尿酸(標(biāo)準(zhǔn)品);8-三羥基嘌呤
英文名稱	Uric acid
英文同義詞	1H-Purine-2,6,8(3H)-trione,7,9-dihydro-;1H-Purine-2,6,8-triol;2,6,8-Trioxopurine;6,8(3H)-trione,7,9-dihydro-1H-Purine-2;7,9-Dihydro-1H-purine-2,6,8(3H)-trione;8(3h)-trione,7,9-dihydro-1h-purine-6;Purine-3,6,8(1H,3H,9H)-trione;PURINE-2,6,8(1H,3H,9H)-TRIONE
CAS號	69-93-2
分子式	C5H4N4O3
分子量	168.11
EINECS號	200-720-7
相關(guān)類別	生化試劑;雜環(huán)砌塊;小分子抑制劑;有機(jī)砌塊;其他生化試劑;小分子抑制劑，天然產(chǎn)物;嘌呤;酸;細(xì)胞生物學(xué)-細(xì)胞氧化應(yīng)激;生化試劑-其他化學(xué)試劑;對照品;有機(jī)化工原料;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Inhibitors;中藥對照品;化工原料
Mol文件	69-93-2.mol
結(jié)構(gòu)式

尿酸 性質(zhì)

尿酸 用途與合成方法

簡介

尿酸是嘌呤代謝的終末產(chǎn)物，體內(nèi)總尿酸的80%由細(xì)胞核蛋白分解代謝產(chǎn)生，20%由攝入富含嘌呤的食物分解代謝產(chǎn)生。尿酸基本上以尿酸單鈉鹽的游離態(tài)形式存在于血液中，因此也稱為血尿酸。

生物活性

Uric acid 是一種內(nèi)源性抗氧化劑，可清除活性氧類化合物 (ROS)，包括單線態(tài)氧，氧自由基和過氧亞硝酸鹽。

靶點

體外研究

Uric acid is an endogenous antioxidant that scavenges reactive oxygen species (ROS) including singlet oxygen, oxygen radicals, and peroxynitrite. Incubation with indomethacin significantly increases malondialdehyde (MDA) levels in Caco-2 cells compare to those not treated indomethacin. Incubation with both indomethacin and Uric acid significantly decreases MDA levels compare to those grown in the presence of indomethacin alone. Co-treatment of cells with indomethacin and Uric acid significantly decreases ROS levels compare to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both indomethacin and Uric acid is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity.

體內(nèi)研究

When mice treated with indomethacin are concurrently administered Uric acid orally, ulcer areas are significantly reduced, in a Uric acid dose-dependent manner. Indomethacin increases the ratio of crypt depth to villous height in the ileum, while the ratio is significantly lower when mice are concurrently administered Uric acid orally. Administration of indomethacin also increases the histopathological score of tissue damage in the small intestine, while mice concurrently administered Uric acid orally has a significantly lower histopathological score. The ileal levels of malondialdehyde (MDA) in indomethacin-induced enteropathy model mice orally administered Uric acid are also significantly lower than the levels in mice administered indomethacin alone.

用途 

用作分析試劑，也用于有機(jī)合成

用途 

用作測定尿酸的標(biāo)準(zhǔn)液

生產(chǎn)方法 

1.取干燥雞糞懸浮于24倍量水中，加入適量氫氧化鈣后靜置。沉淀完全后分出上清液，沉淀中再加水，用硝酸調(diào)節(jié)pH值至3，靜置至沉淀完全。分出上清液，沉淀物再懸浮在水中，以氫氧化鈣調(diào)節(jié)pH值至12～12.5，過濾后濾液以硝酸調(diào)pH值至3，析出物過濾、干燥后即為尿酸粗品。

安全信息

MSDS信息

尿酸 價格(試劑級)

尿酸 上下游產(chǎn)品信息

下游產(chǎn)品

咖啡因次黃嘌呤三聚氰胺一酰胺縮三脲1,3,7-三甲基尿酸